Top-down morphogenesis of colorectal tumors

Top-down morphogenesis of colorectal tumors.

One of the fundamental tenets of oncology is that tumors arise from stem cells. In the colon, stem cells are thought to reside at the base of crypts. In the early stages of tumorigenesis, however, dysplastic cells are routinely found at the luminal surface of the crypts whereas the cells at the bases of these same crypts appear morphologically normal. To understand this discrepancy, we evaluate...

Top down or bottom up? Competing management structures in the morphogenesis of colorectal neoplasms.

the impact of explicit instruction of top-down reading strategies on reading comprehension of intermediate efl learners

this study investigated (a) the learners’ existing reading strategy repertoire, (b) the effect of instruction in reading strategies on learners’ strategic performance, and (c) the effect of explicit instruction in top-down reading strategies on reading comprehension ability of intermediate learners. the study was conducted with 40 intermediate efl learners in two groups of experimental and cont...

Top-down causation without top-down causes

We argue that intelligible appeals to interlevel causes (top-down and bottom-up) can be understood, without remainder, as appeals to mechanistically mediated effects. Mechanistically mediated effects are hybrids of causal and constitutive relations, where the causal relations are exclusively intralevel. The idea of causation would have to stretch to the breaking point to accommodate interlevel ...

Mountains: top down.

Mountainous regions offer not only essential habitat and resources, including water, to the earth's more than 6 billion inhabitants, but also insights into how the global human habitat works, how it is being changed at the moment as global climates are disrupted, and how the disruption may lead to global biotic and economic impoverishment. At least 600 million of the earth's more than 6 billion...